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Analyst Michael King at Rodman & Renshaw argued in September that denosumab could show an efficacy advantage over Reclast.
200 mg once daily doses of sitagliptin did not show an efficacy advantage over sitagliptin 100 mg once daily.
Because of the shorter half-life of dabigatran, poor adherence to the twice-daily dabigatran dosage schedule may mitigate any efficacy advantage over warfarin.
71 An alternative strategy for improving MTX tolerability is twice-weekly dosing, which increases the bioavailability of MTX above once-weekly dosing 72; a preliminary study, however, did not demonstrate an efficacy advantage over once-weekly dosing.
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A rheumatoid arthritis drug, Kineret, is still on track, but doesn't have obvious efficacy advantages over existing drugs.
As both 177Lu and 90Y are used for clinical RIT, we suggest that 177Lu may have combined safety and efficacy advantages over 90Y as a therapeutic β-emitter, at least in treating small tumour volumes[35].
Irinotecan/fluoropyrimidine therapy might be better tolerated when 5-FU/LV is administered as a protracted infusion, and recent data from the NCCTG trial also suggest that combination therapy with infused 5-FU/LV may provide efficacy advantages over those incorporating a bolus regimen (Goldberg et al, 2004).
There was no efficacy advantage of AC over CMF, possibly because of the shorter duration of treatment and the elimination of both 5-fluorouracil and methotrexate from the combination, and over the ensuing 30 years, CMF and AC became references for the development of newer, more effective chemotherapy regimens on both sides of the Atlantic.
They estimated that BUCCOLAM had both an efficacy and an effectiveness advantage over rectal diazepam and off-label buccal use of lorazepam tablets and, in many cases, that it had an effectiveness advantage compared with unlicensed buccal midazolam.
The AVEC's efficacy was at statistically significant advantage over the relevant isotype antibodies.
However, ever since colloids appeared on the scene, debate over their efficacy and potential advantages over crystalloids has continued.
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