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Corresponding to therapeutic efficacy, administration of IL-21R-Fc fusion protein to BXSB.B6-Yaa+/J mice, another model of lupus, decreased lymphocyte activation and circulating IgG1 levels [ 47].
Failure was defined as persistence or progression of signs and symptoms or progression of radiological signs of pneumonia at EOT; termination of study medications due to "lack of efficacy"; administration of any systemically absorbed or aerosolized antibiotic for any reason; death from any cause; an indeterminate response; or relapsed infection at follow-up after termination of study medications.
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To investigate the efficacy of administration of dienogest to thin the endometrium before hysteroscopic surgery and to evaluate the surgical outcome.
This study was designed to evaluate the efficacy of administration of high doses of buprenorphine during 24 h in the management of acute opioid withdrawal.
Aside from the question of efficacy, parenteral administration of fulvestrant has potential clinical advantages in patients with swallowing problems or neurological problems, such as Alzheimer's disease.
The second RCT, MEM-MD-12, assessed the efficacy of administration of memantine (20 mg once daily) versus placebo in patients with mild to moderate AD (MMSE 10-22; n = 433) taking a stable dose of any approved ChEI therapy [ 17].
The first, MEM-MD-02, assessed the efficacy of administration of memantine (10 mg twice daily) versus placebo in patients with moderate to severe AD (MMSE 5-14; n = 404) receiving stable donepezil therapy [ 16].
This can be used as a means to assess comparative efficacy following administration of different aesthetic treatments in the same patient.
The results of this study indicated that pomalidomide was highly effective in patients with dual refractory MM; however, there was no additional benefit in clinical efficacy upon administration of a higher dose of pomalidomide.
Obidoxime exerted the highest therapeutic efficacy at administration of the lowest dose (3.1 mg/kg i.m ., whereas two higher doses (9 and 18 mg/kg) were less effective on most parameters.
We then investigated the efficacy of administration routes of rAAV-/rAdv-hTERTC27 in melanoma growth.
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