Secondary aims are to increase the proportion of eligible children having a body mass index (BMI) recorded and increase GP and Practice Nurse (PN) self-efficacy administering HKC services.
Such an effect has previously been noted in a murine model, in which a pair of T-cell- and antibody-inducing vaccines, each with around 30 35% sterile efficacy when administered alone, elicited 90% sterile efficacy upon their combination.
Sumatriptan had no efficacy when administered 90 post-AITC injection (Fig. 4) as has been reported in humans where the efficacy of triptans is attenuated if patients wait to take the drug [8].
Ibandronate is a potent, nitrogen-containing bisphosphonate with significant antifracture efficacy when administered daily and in regimens with extended between-dose intervals.
Intriguingly, a combination of immunogenic lipopeptides of ESAT-6 antigen exhibited local (pulmonary) and systemic immune responses along with efficient protective efficacy when administered intranasally or subcutaneously.
Licensed neuraminidase inhibitors for influenza therapy, Zanamivir and Oseltamivir, show efficacy when administered within a 48-hour window after the onset of symptoms, but are increasingly compromised by pre-existing or emerging viral resistance [6], [7], [8].
Only the 600 mg/day dosage showed efficacy when administered BID (P ≤ 0.001).
Raltegravir has recently shown efficacy when administered with alternate NRTI backgrounds.
However, many of these drugs did not show efficacy when administered in humans.
Herbal remedies and the osmolyte mannitol have shown limited efficacy if administered in an appropriate time window [ 7, 8].
