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They addressed important broad questions of safety and efficacy 1 and mortality and morbidity 2 associated with this method.
The different regions appeared to confer RNAi with similar efficacy; 1 of 4 TIR, 2 of 17 NB, and 4 of 12 LRR trigger sequences abrogated resistance.
Clinical signs in dog 3 resolved in 4 days, while the dog was receiving ceftriaxone, which has no known anti-rickettsial efficacy (1 ).
Similar simulations were done for equations (12) and (13) with d = 1 and various values of μ0 and efficacy (1 minus the odds ratio).
A total of 38 patients were evaluable for efficacy: 1 patient (3%) had a partial response (PR), 10 patients (26%) had stable disease, and 27 patients (71%) had progressive disease after two cycles of therapy (Table 4).
Similar(55)
The importance of our approach is highlighted by observations of epitope-linked differences in HIV-1-specific CD8+ T-cell efficacy [ 1, 27– 30], which can further segregate at the level of individual TCR clonotypes [ 31, 32].
In spite of the earlier evidence and appeal of GDT that is based on CO maximization, many recent studies have failed to demonstrate its efficacy [ 1, 54, 55].
Furthermore multi-target ligands often possess improved efficacy [1].
Since orthodontic aligners were launched on the market, they have been in growing demand among patients, especially adults, thanks to their aesthetic properties and clinical efficacy [1].
In spite of the earlier evidence and appeal of GDT that is based on CO maximization, many recent studies have failed to demonstrate its efficacy [1, 54, 55].
There is an ever-increasing demand for the discovery, validation, and application of clinically useful molecular biomarkers that enable patient stratification, diagnosis, monitoring of disease progression, or a better understanding of drug response (safety and efficacy) [1]-[3].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com