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Moreover, adjustments in tasks or in working hours, different discussion topics during annual progress interviews, taking the private situation of employees into consideration or simply offer a genuine listening ear every now and then may be efficacious to maintain or improve the workability of employees.
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Although perhaps dronedarone is the most efficacious drug to maintain sinus rhythm and control ventricular rate should atrial fibrillation recur, its use comes with the risk of adverse effects that make the drug untenable to many treating physicians and patients alike.
Although modification of MSCs to overexpress HGF has an effective means to maintain or enhance the capacity of MSCs and to be efficacious for bladder fibrosis therapy [ 20], the choice of vector for cell transduction should be carefully considered.
Subsequent antimalarial trials conducted in Southeast Asia and Papua New Guinea have continued to demonstrate high rates of P. vivax infection post-treatment, especially when follow-up is continued beyond the period when the antimalarials used are expected to maintain efficacious drug levels in the bloodstream [6], [7].
Overall, our studies suggest that to maintain efficacious levels of therapeutics throughout disease progression adjusting doses of elacridar (or other more potent and selective P-gp/BCRP inhibitors yet to be developed) may be the most valuable solution.
5-chloro-2,4-dihydroxypyridine is a competitive inhibitor of dihydropyrimidine dehydrogenase, which is involved in the degradation of 5-FU, and acts to maintain efficacious concentrations of 5-FU in plasma and tumour tissues (Tatsumi et al, 1987).
Non-invasive time-course measurements may deliver apt information both on the efficacious dose as well as the dosing intervals required to maintain the targeted efficacy using a minimum of experimental animals.
Although efficacious as an anticoagulant, patients on warfarin require close monitoring to maintain optimal coagulation levels: if under-coagulated, the patient is at risk of a thromboembolic event; if over-coagulated, there is a risk of bleeding complications.
Collectively, literature data demonstrate that RBCs represent not only an efficacious mechanism to counteract oxidative stress but also a further tool to maintain immunological homeostasis.
But Cristofori's sophisticated and highly efficacious mechanism was "ahead of its time". Musicians initially considered it too expensive and difficult to maintain in adjustment.
No hair to maintain.
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CEO of Professional Science Editing for Scientists @ prosciediting.com