Both vaccines were found to be safe and efficacious in large studies powered to detect intussusception risk [ 10- 13].
Beyond RA, the continued development and use of dichotomous measures of response in rheumatic diseases may be sacrificing our ability to detect whether treatments are efficacious.
Since the percent of gel use among risky acts (i.e., with an HIV-infected partner) without condom use is a major determinant of the overall level of effectiveness that can be observed for a truly efficacious product, unless gel use can be increased, studies designed to detect a 50% effect may not be able to identify truly efficacious products[12].
The recent SADHART (Sertraline AntiDepressant Heart Attack Trial) investigation demonstrated that sertraline is safe and efficacious in depressed patients with ischemic heart disease but was underpowered to detect a mortality difference between sertraline and placebo.
Phenotype screening based on standardized behavioral tests [ 31, 51] combined with neuroimaging [ 50] to detect enlargement of the lateral ventricle may be an efficacious approach for the identification of robust schizophrenia models.
Several studies have demonstrated the ability of functional imaging techniques to detect subclinical alterations in tumour physiology and biochemistry resulting from efficacious therapy [ 1, 6, 13, 15, 18, 20].
Calculated as the proportion of simulations with a positive or negative vaccine efficacy when true efficacy is 0%, and the epidemic is non-extinct at t. Power to detect vaccine efficacy the probability that a positive vaccine effect can be detected given that the vaccine is efficacious and the epidemic is non-extinct.
Efforts are currently underway to develop platforms to detect and quantify the human zinc spark in a non-invasive, safe, and efficacious manner.
It has proven to be efficacious for screening (Atkin et al, 2010; Holme et al, 2013; Schoen et al, 2012), although cannot be used to detect the ∼40% of tumours that develop in the proximal colon (Whitlock et al, 2008).
They know what to detect".
