Sentence examples for efficacious target from inspiring English sources

We therefore propose c-CBL as an efficacious target for lung cancers in African-Americans that needs to be further substantiated.

This in turn suggests that EP2/survivin may be an efficacious target for chemoprevention or therapy of skin cancer [ 60].

Overexpression of E2F1 promotes the development of MDR in gastric carcinoma, suggesting that E2F1 may represent an efficacious target for gastric cancer therapy.

Because of its impact on cell-growth and -survival pathways, E2 signaling has proven to be an efficacious target for ER-positive breast cancer therapy.

Translational PK-PD modeling can support the design of FIH studies by providing estimates of efficacious target exposures, associated dose regimens, and guidance in selection of biomarker and optimal sampling time points for exposure and biomarkers.

Given previous reports that the transformation activity of KRAS is dependent on RAC1 (Qiu et al., 1995), it seems likely that RAC1 would remain an efficacious target even in the setting of a KRAS mutation.

Literature evidence supports the hypothesis that computationally identified fragile cell-cycle interactions represent efficacious targets.

Those data could provide biomarkers, and could lead to the development of novel efficacious targets to treat pituitary adenomas.

Thus, there is a need to identify new effectors in this important pathway that might prove to be more efficacious targets.

The present data show that the inhibition of β-catenin and/or STAT3 suppresses gastric carcinogenesis, suggesting that these molecules are efficacious targets for the medicinal treatment of gastric cancer.

Given the degree of reported impairment based on PedsQL™ scores across different pediatric chronic conditions, the need for more efficacious targeted treatments for those pediatric patients with more severely impaired HRQOL is clearly and urgently indicated.