Alternative platforms to construct ZFNs have since emerged, and these show variation in speed, site selection and success in generating efficacious ZFNs (Sander et al., 2011; Gupta et al., 2012; Bhakta et al., 2013).
Efficacious treatments have been tested with success for both depression [ 2] and AOD disorders [ 3], suggesting that this burden can be reduced.
Also, the relative success of different components of efficacious interventions is unclear in addition to the optimal intervention intensity.
Smoking cessation treatments are efficacious in some smokers, but overall treatment success is modest (20-40%), reflecting heterogeneity in treatment response [ 1].
Even for the programs that are deemed "successful," because people aren't collecting consistent data, we're not in a good position to tease out which aspects of the programs are the efficacious ones, and which aspects aren't necessary for success.
However, achieving clinical translation and commercial success requires regenerative biomaterials to be not only efficacious and safe but also cost-effective and convenient for use and production.
The success of a flexible assembly line (FAL) depends on efficacious scheduling and control architecture.
Successful neonatal vaccination would be an efficacious and cost-effective way to protect lambs from disease during the perinatal periods but this is largely not practised due to the limited success reported for vaccination using parenteral vaccination methods [ 3- 5].
Despite the lack of success to date, much effort is being made to develop efficacious medications for treating ATS addiction.
Finally, if it is known that treatment efficacy is optimal for one certain genotype group, while a similar drug is most efficacious for another genotype group, therapy can be personalized to achieve maximal success in patient care.
