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Simply targeting the IGF-IR or the IGF system in isolation may therefore not be the most efficacious strategy for treating this disease; more complex therapeutic approaches to target the IGF system and prevent tumorigenesis and, in particular, metastasis, are likely to be required.
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The inhibition of the PI3K pathway and downstream mammalian target of rapamycin (mTOR) has been identified as a promising therapeutic strategy for treating TNBC, and a phase 2 trial demonstrated that everolimus (mTOR inhibitor -carboplatin combinhibitor -carboplatins in metastaticombination].
Blair, P. A. et al. Selective targeting of B cells with agonistic anti-CD40 is an efficacious strategy for the generation of induced regulatory T2-like B cells and for the suppression of lupus in MRL/lpr mice.
We believe that dimension reduction techniques provide an efficacious strategy for the analysis of survey data.
Training health professionals to give advice, in isolation, is probably not an efficacious strategy for smoking cessation (level of evidence: A).
The findings could open a new strategy for treating cancer.
Anti-angiogenesis therapy is a key strategy for treating NSCLC.
du Bois, R. M. Strategies for treating idiopathic pulmonary fibrosis.
Recent guidelines [ 15] outline strategies for treating recurrent CDI.
A wide variety of systemic therapeutic strategies to directly target hypoxic tumour cells have been clinically tested in combination with radiation therapy in order to improve loco-regional control of primary tumours, and there is a clear need for new and efficacious strategies to treat (or manage) metastatic disease.
Understanding why athletes do or do not report their symptoms is critical for developing efficacious strategies for risk reduction.
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CEO of Professional Science Editing for Scientists @ prosciediting.com