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The success of a flexible assembly line (FAL) depends on efficacious scheduling and control architecture.
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Feasibility of an efficacious dosing schedule is indicated from studies with rats [ 26].
Participants stepped down the nicotine patch levels according to a known efficacious dosing schedule: a 21 mg patch in weeks 1 to 6, 14 mg patch in weeks 7 to 8, and 7 mg patch in weeks 9 to 10 [ 36].
The rate at which S6K1 activity subsequently recovered differed, with everolimus doses that were efficacious with weekly schedules causing more profound long-term effects on S6K1 activity (≥7 days).
This efficacy is schedule dependent, with a daily-for-8-days schedule being more efficacious than 4- and 1-day schedules.
In fact, it has been previously reported that weekly administration of paclitaxel has superior efficacy over the three weekly schedule coupled with different toxicity profile [ 6, 10] while weekly docetaxel schedule proved to be at least as efficacious as tree weekly schedule [ 6, 11].
Data regarding the most efficacious and least toxic schedules for the use of colistin are scarce.
It hence appears that the regimen reported here is possibly as efficacious as the hypofractionated CRT schedules, albeit with the absence of significant toxicities, most likely reflecting the reduced fraction size.
However, we cannot assume that other schedules will be equally efficacious against malignant mesothelioma without appropriate clinical trials.
In the adjuvant setting, the Eastern Cooperative Oncology Group (ECOG) 1199 trial further supported this schedule of paclitaxel as efficacious and tolerable [ 20].
We show in the current study that this schedule is tolerable and efficacious in patients with both AML and advanced MDS.
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