However, unlike most proteins and peptides, NA must be delivered to the cytoplasm or nucleus to be efficacious, resulting in significant delivery challenges.
But the product was not clinically efficacious, resulting in the termination of the project.
The combination of capecitabine and MMC is efficacious, results in symptom relief and is well tolerated as third-line treatment of metastatic CRC.
Previous studies have examined the effects of vIL-10 in the AIA rabbit model as well as the collagen induced arthritis mouse model showing efficacious results for treatment [ 11, 12, 32, 33].
We found that a lifestyle intervention program in obese endometrial cancer survivors is feasible and efficacious – resulting in sustained behavior change and weight loss over a one year period.
We aimed to investigate the hypothesis that an initial administration of a short course of oral prednisolone would lead to more efficacious results from subsequent nasal steroid therapy in the treatment of nasal polyposis.
In addition, in the intracranial model, the combination treatment was more efficacious, resulting in a 73% decrease in tumour volume 25 days after the start of therapy, as well as in a longer survival of the animals.
In light of the Phase III population level vaccine trial completed in Thailand in 2009, which only showed moderately efficacious results, it is important to understand how the media are communicating the reality of partial protection, and how individuals may understand partial protection risk messaging when, or if, it is communicated [ 24].
In addition, strict adherence to ' local is best' protocols may encourage the selection of inbred or genetically depauperate seed sources (Broadhurst et al. 2008), when genetically healthier sources further afield may produce a more efficacious restoration result (C. Navarro, S. Cavers and A. Lowe, unpublished data).
Aromatase inhibitors might be more efficacious, and results of prevention trials are eagerly awaited.
