The non-efficacious rate for drug combination usages in early development stages is 15.1%, and, that in late development stages is similar, i.e. 17.8%.
Therefore, more efficacious treatment employing modalities that would entail minimal adverse effects, high efficacy rates and prolonged survival is needed.
In comparison with non-ICU patients, critically ill patients admitted to ICUs may receive more benefit from mupirocin, even when moderately efficacious, because the rate of S. aureus infections in ICU patients is much higher.
For example, a meta-analysis of the RCTs of antidepressants for treatment of depression in AD concluded that treatment was efficacious with discontinuation rates that were equivalent to placebo [ 71].
In the search for differences between statins, this study showed that fluvastatin, the least efficacious, had the lowest rate of adverse events, and atorvastatin, the most efficacious, had the highest rate.
In this particular patient group capecitabine and bevacizumab was feasible and efficacious with a response rate of about 20% and a median PFS of 9.1-11.5 months.
Conclusions In patients undergoing primary PCI, unfractionated heparin plus GpIIb/IIIa inhibitor and LMWH plus GpIIb/IIIa inhibitor were most efficacious, with the lowest rate of major adverse cardiovascular events, whereas bivalirudin was safest, with the lowest bleeding.
Zhang et al 25 reported that in 142 Chinese patients with coronary heart disease, the rate of efficacious response to GTN was significantly higher in patients with the *1/*1 genotype than in those carrying the *2 allele.
While not designed to test the efficacy of AD on CRC screening rates, we found evidence to suggest that AD may be efficacious in increasing screening rates in some practices.
Studies have shown that antibiotic therapy for more than 5 days is more efficacious in reducing infection rates than periods of only 24 hours [ 6].
Further studies are needed to determine whether HIT programs, perhaps in the less intense form or as an adjunct to moderate-intensity exercise, would be effective in the long-term and have a high enough adherence rate to be efficacious.
