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It is entirely possible that amyloid-modifying therapies will be maximally efficacious prior to any cognitive impairment.
This undermines any incentive to invest upfront resources to establish ingredients as safe and efficacious prior to reaching consumers.
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For example, TVR and boceprevir were compared in a MTC meta-analysis [ 23], and the indirect evidence suggests that TVR may be more efficacious for prior relapse but not for treatment naïve patients.
Treatment with these drugs, as with passive transfer of neutralizing antibodies, is only efficacious in hamsters prior to the onset of viremia.
These and later studies demonstrated that antiretrovirals were most efficacious if given prior to or within hours after HIV or SIV challenge, and continued for 4 weeks.
Interestingly, the peri-conceptual timing of these successful interventions suggests that in women, Treg cell boosting might be efficacious if achieved even prior to the index pregnancy.
Therefore, the pre-selection of high-risk individuals with a simple and efficacious non-invasive biomarker, prior to endoscopic examination, has been proposed as a reasonable strategy for gastric cancer mass screening.
The findings indicated that the most efficacious method of skin antisepsis prior to IV site insertion was the use of CHG (0.5 per cent) with 70percentnt isopropyl alcohol swab.
The efficacy of alprazolam in ADWA is consistent with prior findings that benzodiazepines are efficacious in the treatment of this condition.
If interim imaging can predict early in the course of therapy that a specific treatment will not be efficacious, therapy can potentially be altered prior to completion of the entire course.
Studies suggested the most efficacious time for GT3 administration is 24 h prior to irradiation, possibly due to the induction of key hematopoietic cytokines.
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