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This schedule was chosen to determine the effects of INH during its most efficacious period, on the basis of previous bactericidal activity studies [57], assuming that the CFU control would start at week 5 after challenge, as previously demonstrated in guinea pigs [58].
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They investigated the effects of HAART on HIV incidence and prevalence, assuming different average efficacious periods and assimilation times for HAART, different infectivity probabilities when receiving HAART, and different increases in the mean number of sexual partners.
This strategy proved very efficacious during the period of prophylaxis, but this effect faded off after drug withdrawal as the HIV exposure continued [ 11, 12].
Our data show that continuous treatment with etanercept over such a long time period was efficacious and safe.
However, studies have also demonstrated the administering the first dose of the rotavirus vaccine in the neonatal period proves efficacious and affords protection early on in life [ 40].
74 Targeted therapies directed at oncogene-addicted tumors often are efficacious for a limited period of time before the onset of acquired resistance.
Thus, we conducted a meta-analysis of all RCTs in this area to determine whether TAP block is more efficacious during the postoperative period of lower abdominal surgery in adults.
Because CBZ and OXC are extremely efficacious in increasing the refractory period of action potentials, they are bound to be most active on the high-frequency discharges that characterize the paroxysms of trigeminal neuralgia.
For optimal anticancer treatment with cytotoxic drugs, it is necessary to sustain antitumor effects over a prolonged period at an efficacious drug concentration without inducing severe systemic toxicity.
To make use of this "window" period in an effective, efficient, and efficacious way, it is imperative to understand the underlying biology of early periodontal responses to tooth movement after augmented corticotomy and to develop appropriate clinical procedures.
Studies have shown that antibiotic therapy for more than 5 days is more efficacious in reducing infection rates than periods of only 24 hours [ 6].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com