Because activation of Tregs is a major way in which UVR suppresses cutaneous immunity, we hypothesized that successful UVR-induced therapeutic hardening was efficacious, in part, by boosting Treg numbers and/or function.
Even though pentavalent antimonials continue to be efficacious in other parts of Southeast Asia, the WHO currently recommends alternative drugs (AmBisome infusion) as the first line therapy options in this region.
Despite these promising outcomes, little consensus exists as to whether 1 treatment is more efficacious than others, in part because cross-study differences in methodology render meta-analyses difficult, and in part because many studies fail to document duration of treatment effects or generalization to daily activities.
Chemotherapy alone is associated with high toxicity and poor overall survival benefit with evidence to suggest chemotherapy is efficacious when used as part of multimodality therapy.
Before then the Italian data were exceptionally high due, according to La Vecchia (personal communication), to delay in adopting efficacious modern therapies in some parts of the country and partly to some national quirk of classification.
Yet this efficacious magic doesn't actually form part of the piano's aesthetic impact.
Systemic acting treatments might be more efficacious in a joint that is part of a generalized OA than in a joint-specific local OA where biomechanical factors may largely contribute to the disease.
In summary, evidence suggests that regimens including PLD as part of a combined therapy are efficacious and safe as a first-line treatment for MBC.
This need to inform consumers would also apply to those complementary medicines where evidence indicates they are efficacious and appropriate, and should be considered as part of an evidence-based therapeutic regimen.
Second, any prevention option that is less efficacious than condoms would have to be introduced as part of the existing HIV prevention messages in order to avoid a reduction in condom use among people willing and able to use condoms.
