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In another study [ 16], levetiracetam was found to be efficacious initially, but 6/9 responders experienced an increase in seizure frequency after 4 8 months.
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802-2 treatment during PLP139 151 induction of EAE rendered the mice more resistant to subsequent rechallenge with antigen, and was also efficacious when initially administered during a secondary EAE response.
For policy this should be interpreted with caution in this area; in East Africa this initially efficacious combination rapidly lost its efficacy in children.
Instead, recurrent AK was always retreated using the same initially efficacious treatment.
Initially, this mechanism is deemed efficacious.
But Cristofori's sophisticated and highly efficacious mechanism was "ahead of its time". Musicians initially considered it too expensive and difficult to maintain in adjustment.
The CYC plus prednisone approach has been one of the main regimens to treat membranous nephropathy [ 6], and initially, we felt that this approach would provide efficacious treatment of both glomerulopathies.
There are currently more than 35 ADCs in clinical development, and even though some promising results have been reported, the available data suggest that developing highly efficacious therapeutics through this modality may be more complex than initially expected.
The program, initially designed for beef cattle, was recently shown to be efficacious in dairy heifers.
Chest radiography (CXR) was initially used for screening, but was not proven to be efficacious because of its limitations in detecting smaller tumours.
Lithium is efficacious as maintenance therapy, but is not as highly effective as early studies initially suggested (abrupt discontinuation of lithium probably increased placebo relapse figures).
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