Sentence examples for efficacious in suppressing from inspiring English sources

Surprisingly, it was found that having both activities in a single compound was significantly more efficacious in suppressing GH from acromegalic tumors than the individual SST and DA agonists, either used alone or in combination.

A paritaprevir-ritonavir dose of 150/100 mg was more efficacious in suppressing R155K in NS3 than a 100/100-mg dose.

43, 44 Recently, flecainide therapy has been advocated to be efficacious in suppressing ventricular arrhythmias in CPVT as well as certain ATS patients.

Adalimumab in combination with low-dose MTX was well tolerated and efficacious in suppressing radiographic progression and improving clinical outcomes in Japanese patients with early RA and high disease activity.

In p27-/ mice hormone stimulation for 60 days further increased PIN multiplicity (2.3 ± 1.2 per animal) as compared to p27+/+ and p27+/- mice, but 9cRA was again not efficacious in suppressing the neoplastic process (Table 4).

Adoptive transfer of antigen-specific Tr1 cells has been shown to be efficacious in suppressing inflammation in a variety of animal models for chronic inflammatory and autoimmune diseases, such as colitis, type 1 diabetes, multiple sclerosis, allergy and transplantation [ 20, 24- 28].

46 For targeted pharmacotherapy, simulated electropharmacological testing suggests that combination therapy with a Ca2+-channel blocker and an Iup (SR Ca2+-ATPase current) inhibitor is more efficacious than a Ca2+-channel blocker alone in suppressing CPVT-associated arrhythmias.

Rapid contact tracing in ring vaccination may play an important role in suppressing the epidemic, since the longer it takes to trace a contact, the less likely the vaccine is to be efficacious, and the more opportunities the infected individual may have to transmit disease before they are finally located, isolated, and vaccinated if appropriate.

Although comparable efficacies were seen with all doses of paritaprevir/r studied, the infrequent emergence of R155K in patients with VF at a dose of 150/100 mg suggests that this dose was more efficacious at suppressing this variant, which confers 37-fold resistance, than the 100/100-mg dose; hence, in the phase 3 development program, paritaprevir/r was dosed at 150/100 mg.

Of interest, in MCF-7 xenografts Lipo-P-I (which was more efficacious in tumor growth inhibition than free P-I) suppressed Trx-1 expression and TrxR activity to a greater extent than free P-I, suggesting that this effect may be part of the mechanism of action for P-I.

These results suggest that heat shock is efficacious in the prevention of MMP-dependent ECM remodelling in the process of angiogenesis by suppressing the production of tumour-derived VEGF.