The inclusion of efficacious CAM therapies in such an environment has the potential to enhance outcomes and warrants further research.
Owing to the di- and trimethylated Se metabolites are very rapidly excreted across the lung (dimethylselenide, [CH3]2Se) or kidney (trimethylselenonium, [CH3]3Se+), they are not efficacious in such models.
However, it is reasonable to believe that moral actions will be causally efficacious in this way only if the laws of causality are set up in such a way that these laws are conducive to the efficacy of moral action.
These characteristics could be a disadvantage for evaluating drug candidates that are moderately efficacious and could be overlooked when tested in such an aggressive model, as opposed to the common more moderate models which may recapitulate the slower progression of AD in humans.
In 2008, we can speculate that a PCT-guided antibiotic strategy in the ICU might be efficacious but such a strategy must be properly tested in a heterogenous group of critically ill patients.
More recently, eculizumab has emerged as an efficacious therapy in such patients, either with or without plasmapheresis treatment [ 9].
One such strategy might include incorporating large amounts of natural compounds thought to have an anticancer effect either in diet or to ingest a dietary supplement containing an efficacious quantity of such a compound.
Whether some DMARDs are more efficacious than others in such early (or very early) disease remains a matter of debate.
It is important, however, to recognize that CT scan is the primary and most efficacious diagnostic tool in such patients.
In view of the unmet clinical need for more efficacious haemostatic agents in such patients, clinical studies are now justified to confirm the observed favourable effects of PCC in the present preclinical model system.
