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Vaccine vectors derived from adenoviruses have been shown to be efficacious in a number of animal species showing susceptibility to different infectious agents [18], [19].
Such novel molecules have substantially higher levels of activity relative to membrane-free sCD59 and have been found to be efficacious in a number of animal models of disease [17], [18], [19].
These authors also showed that an anti-mouse CD40L domain Ab was efficacious in a number of mouse models of autoimmune disease.
Although proven to be efficacious in a number of clinical indications, their use is associated with a high risk of bleeding.
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As discussed, RTX has been shown to be efficacious in a growing number of small case series in steroid-sensitive and steroid-dependent MCD; however, reported success of its use in multi-drug-resistant disease, particularly in adults, remains limited.
We previously demonstrated that a selective retinoid X receptor (RXR) agonist bexarotene (LGD1069, Targretin) is an efficacious chemopreventive and chemotherapeutic agent in a number of preclinical rodent models breast cancer (Boehm et al, 1994; Gottardis et al, 1996; Wu et al, 2002a, 2002b).
76 By contrast, prolonging the LD half-life via adjunctive treatment with a catechol- O-methyltransferase inhibitor, such as entacapone or tolcapone, has been found to be efficacious in reducing daily "off " time in a number of well-performed, randomized, controlled trials in PD patients with wearing-off.
Rituximab is an efficacious drug for a number of pediatric conditions.
Further, empagliflozin was shown to be efficacious in a patient population that included a substantial number of patients with a long duration of type 2 diabetes (77% of randomized patients had been diagnosed >5 years before the trial).
Should this trial demonstrate that azithromycin is efficacious in reducing the number of pulmonary exacerbations, it will provide a much-needed rationale for the use of long-term antibiotics in the medical management of bronchiectasis in Indigenous children.
Alone or in combination, these agents have proved to be efficacious in the treatment of angina pectoris or other symptoms of ischemic heart disease in a number of patients, but certainly not in all.
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