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However, the common use of more efficacious high doses of CQ in Guinea-Bissau probably turns pfcrt 76T into a marker of tolerance.
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Given the considerable evidence pointing to a contributory role for IL-6 in SLE pathogenesis, the a priori likelihood that therapeutic targeting of this pathway in SLE will be efficacious is high.
This weakening of explosions was more efficacious for higher concentrations of methane than it was for lower concentrations of methane.
Ideally, the next generation of treatments for nosocomial and community-acquired infections, including those caused by Candida spp, Aspergillus spp, Cryptococcus spp and Fusarium spp, will be more efficacious, with higher therapeutic indices and broader activity spectra than existing antifungal drug classes.
Many interventions shown to be efficacious in high-income countries are not similarly effective when carried out in other contexts [26], [27].
It is still unclear if interventions are more efficacious in higher risk patients.
Iron isomaltoside 1,000 was more efficacious with higher cumulative doses of >1,000 mg IV.
For therapeutic purposes, however, 1 mg seems to be as efficacious as higher doses (Table 3, Figure 2).
40 Moreover, O'Brien et al showed that rituximab was more efficacious at higher doses in CLL patients.
Based on current research, β-alanine supplementation appears to be efficacious during high-intensity activity lasting 60 360 s.
Transjugular renal biopsy appears to be efficacious in high-risk patients, for whom the percutaneous approach is contraindicated, including patients on oral anticoagulation.
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