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37 A meta-analysis of head-to-head studies comparing orlistat and sibutramine indicated that sibutramine was significantly more efficacious for achieving weight loss than orlistat, with the weighted mean difference in weight loss of 2.2 kg favoring sibutramine.
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Although some studies indicate that intravenous iron is in general more efficacious than oral iron for achieving increases in Hb in patients with CKD, oral iron is also effective (55).
Febuxostat 80 mg was significantly more efficacious than febuxostat 40 mg or allopurinol for achieving the primary efficacy endpoint (p < 0.001 for both comparisons).
Febuxostat 80 mg was significantly more efficacious (82.0%) than febuxostat 40 mg (61.7%; p < 0.001) or allopurinol (47.3%; p < 0.001) for achieving the primary efficacy endpoint.
Despite the development of pharmacologically active molecules being a multifactorial optimization problem, where other considerations too, such as bioavailability and toxicity, play an important role, high affinity of a compound for its intended biological target is a necessary requirement for achieving a potent, selective and ultimately efficacious drug.
Remote loading of liposomes by transmembrane gradients is one of the best approaches for achieving the high enough drug level per liposome required for the liposomal drug to be therapeutically efficacious.
UCSF has a strategy for achieving that.
And Ruxin's suggestion for achieving that?
Include rewards for achieving goals.
Assess your options for achieving your priorities.
Meditation helps a lot for achieving this.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com