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Feasibility of an efficacious dosing schedule is indicated from studies with rats [ 26].
In an accompanying editorial it was suggested that development of more standardized and efficacious dosing regimens would be preferable [ 8].
At the maximal efficacious dosing regimen (100 mg/kg/day), administration of 2ME2 resulted in total inhibition of the study parameters and prevented neovascularization into the joint.
Pharmacometric modelling and simulation are also advocated by regulatory bodies to support the selection of safe and efficacious dosing regimens for children [ 17, 18].
A better understanding of how these cellular components work together to combat environmental stresses could lead to new strategies for more efficacious dosing of existing antibacterial agents as well as the development of novel therapeutics.
Importantly, the use of Vk*MYC MM allowed us to document the lack of activity of ABT-737 when combined with panobinostat and identify a toxicity profile observed following combination of panobinostat with MD5-1 that restricts efficacious dosing of this dual treatment regimen.
Similar(52)
The two chemicals have similar potency and efficacy, and the same most efficacious dose around 10 9 to 10 8 M.
Non-invasive time-course measurements may deliver apt information both on the efficacious dose as well as the dosing intervals required to maintain the targeted efficacy using a minimum of experimental animals.
One can only hope that the issues raised – namely what is actually the minimum effective dose, how best to administer possibly partially efficacious doses to reduce the burden of disease, and how to improve vaccine yield – will better prepare us in our ongoing battle with this very old enemy.
However, this differentiation diminishes at the maximum efficacious dose.
The use of non-chelated formulations determines diarrhoea at clinically efficacious doses.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com