Sentence examples for efficacious dose of the from inspiring English sources

The co-administration of a low but efficacious dose of the compound with doxorubicin is well tolerated in mice.

For example, in many cases the preclinical efficacious doses of these drugs vastly (several orders of magnitude) differed from doses used in clinical practice [ 40].

Importantly, the use of Vk*MYC MM allowed us to document the lack of activity of ABT-737 when combined with panobinostat and identify a toxicity profile observed following combination of panobinostat with MD5-1 that restricts efficacious dosing of this dual treatment regimen.

When different physostigmine doses were combined with the most efficacious dose of obidoxime (3.1 mg/kg), again the dose of 0.3 mg/kg physostigmine showed the highest efficacy.

In this study, and the studies of Chander et al (2007) and Foster et al (2008a), daily dosing with STX140 did not cause significant weight loss and there were no gross signs of damage to the normal vasculature, indicating that the efficacious dose of STX140 lacks toxicity.

The objective of the present study was to identify the most efficacious dose of Q-Gel for use in supplementation studies.

Conclusion(s): In postmenopausal women with uterine leiomyomas, it is necessary to use the minimal efficacious dose of progestin during HRT because of a higher risk to increase the tumors dimensions.

To determine the lowest efficacious dose of oral meloxicam for relieving pain in cats with a sodium urate (SU -induced acute inflammatory SU -induced

Work using mice not only supports the results found using cell lines, but when extrapolated to humans, indicates that an efficacious dose of tocotrienols could be consumed from the diet ([He et al. 1997]).

Consequently, ASA guidelines advocate that the lowest efficacious dose of neuraxial opioids be used to minimize this risk [ 14].

The predetermined efficacious dose of 40 mg/kg daily in mice maintains plasma Sunitinib concentration above 50 ng/mL, selectively inhibiting VEGR2 and PDGF receptor phosphorylation [ 26].