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Involved parties need to understand the fundamental perspectives across disciplines to collaboratively achieve an efficacious design.
This is somewhat surprising given the wealth of literature outlining basic principles and guidelines for efficacious design of such messages [ 38].
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This information would contribute to efficacious vaccine design against a broad array of norovirus strains.
These findings provide new insights into the rational engineering of VLP vaccines, and could ultimately enable safe and efficacious vaccine design as an alternative to conventional approaches necessitating pathogen cultivation.
While the identification and prioritization of chlamydial antigens is a crucial prerequisite for efficacious vaccine design, it is likely that novel adjuvant development and selection will also play a pivotal role in the translational potential of preclinical Ct vaccines.
Hence, the peptides may be efficacious in designing new chemotherapeutic for the management of EAEC mediated diarrhea.
Tracing the ontogeny of ACOA behavior using measurable units of response not only makes scientific sense, but also is clinically more efficacious for designing treatment intervention.
Power calculations suggest a chronic HCV infection rate of at least 12/100 py (primary HCV infection rate 16/100 py) will be required for stand-alone trials of highly efficacious candidates designed to prevent chronic infection.
6 Three complementary types of experts, usually working in tandem, are necessary to design efficacious and effective interventions capable of being disseminated and adopted by the wider community: researchers (ie, content experts), clinicians, practitioners and policy makers (ie, process experts), members of the target community, sports bodies (ie, context experts).
In conclusion, the introduction of a methanesulfonamide group is effective to design less lipophilic, more efficacious and more bioavailable indoline-based ACAT inhibitors than previous indoline-based inhibitors.
However, in order to design efficacious anti-remodelling agents we first need a greater understanding of the molecular mechanism/s underlying the development of airway remodelling.
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