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It has already been shown that both technological and policy-related factors contribute to efficacious data sharing [23, 24].
In a previous experiment in which the control animals had nearly 10 carcinomas per rat, celecoxib was not efficacious (data not shown).
Given the need for comprehensive, resource-efficient, and efficacious data, information, and knowledge management in the majority of basic, clinical, and translational research programs, investigators and their collaborators increasingly expect that CS/IS/IT and BMI methods and platforms, intended for use in such capacities, are made accessible to them in a high-availability manner.
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Table 3 summarises the outcomes and median dose used for the different combination therapies, and Fig. 2 illustrates the efficacy data of the four most efficacious combinations.
Our earlier in vivo efficacy data on TMC207 in the guinea pig model showed the 15 mg/kg dose as a safe and highly efficacious dose [23].
For making intelligent decisions based on data, efficacious analytic methods are required.
If the high dose CQ treatment commonly used in Guinea-Bissau is efficacious as our data suggests, pfcrt 76T carrying parasites will lose much of their survival advantage and therefore not accumulate markedly during the high transmission season.
In clinical trials, pharmacological inhibitors of PDE4 developed as potential therapies for treatment of inflammatory diseases were less efficacious than preclinical data suggested [18], [21], [22]; consequently, none has yet been approved for clinical use [23], [24].
Several chemo-triplet schedules with 5FU/LV or capecitabine, irinotecan and oxaliplatin were evaluated with the Italian FOLFOXIRI demonstrating the most efficacious and reliable data [ 37, 43- 46].
Most of the playing was as efficacious and numbing as data entry.
Although the general PFI approach (grouping together commercially branded and unbranded programs) and PNF approach seem to be efficacious on the whole, data are insufficient to make general recommendations regarding the best program for adoption.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com