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In other words, "more mindful people were more likely to find benefit in adversity, which resulted in them believing themselves to be more efficacious after failing," says Hanley.
In the former, new drugs with improved efficacy and reduced toxicity entered the clinic; in the latter, immune-checkpoint inhibition proved efficacious after chemoradiotherapy for stage III disease, but had disparate results in the frontline treatment of stage IV disease.
Treatment of RA undoubtedly has become more efficacious after the introduction of biologic treatment alternatives but it has also become a major area of concern to health care payers when it comes to the budget impact.
These data suggest that pyrazinamide treatment is still efficacious after 2 months of treatment and suggests that the observed bactericidal synergy with J [33] is extended in the sterilizing phase.
The paradox is obvious and runs thus: 1. Pharmacological prevention of migraine is considered efficacious after decades of research.
Although the mechanistic underpinnings of immune priming are not well understood (but see [ 6, 7]), what is clear is that the innate immune response is more efficacious after a preliminary encounter [ 8].
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More recently, angiotensin receptor blockers (ARB) have become available for use in those patients who develop adverse events from ACE inhibitors; ACE inhibitors and ARBs have been shown to be equally efficacious and effective after MI [ 5– 7].
When compared with the control treatment, significant increases in the total number of leaves per plant were observed for the most efficacious treatments after one year (2 4 leaves more) and after the second year (3 6 leaves more) after initiating the axillary applications of fungicides in both experiments.
Importantly, the N6 variant was therapeutically efficacious even after a 50% reduction of viral dose, thereby indicating that transgene modification itself can improve the dose efficacy of HD-Ad.
Moreover, septic patients need efficacious treatments after the disease has already developed [ 6].
A second aspect coming from the data of the present study is that males seem to have a more efficacious response after exenatide therapy, probably due to their reduced duration of disease as well as to a less exhausted β-cell mass at baseline, as indirectly suggested by the lower rate of males on combination therapy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com