Sentence examples for efficacious administration of from inspiring English sources

The presence of a therapeutic window dictates specific time constraints for efficacious administration of exogenous EPO as a tissue protectant.

We hope that this work will be a step forward towards routine implementation of mathematical models for personalising oncology schedules, and for replacing trial and error methods in drug development by more rational methods leading to efficacious administration of drugs with increased patients' compliance.

Clinical evidence demonstrates coadministration of tumour necrosis factor inhibitor (TNFi) agents and methotrexate (MTX) is more efficacious than administration of TNFi agents alone in patients with rheumatoid arthritis, leading to the perception that coadministration of MTX with all biologic agents or oral disease-modifying antirheumatic drugs is necessary for maximum efficacy.

As already mentioned, in all these models the liposomal delivery of VCN was far more efficacious compared to the intravenous administration of the naked polypeptide.

Therefore, further research should be undertaken in order to gain more insight into the disease molecular mechanisms underlying the biology of BC which may aid in the administration of more efficacious treatments in clinical practice.

At the maximal efficacious dosing regimen (100 mg/kg/day), administration of 2ME2 resulted in total inhibition of the study parameters and prevented neovascularization into the joint.

Despite its favorable clinical efficacy, dose-limiting side effect (such as neuropathy) of oxaliplatin-based chemotherapy prevents administration of the full efficacious dosage and frequently leads to treatment withdrawal (Avan et al., 2015; Martinez-Balibrea et al., 2015).

In vivo experiments demonstrate that oral administration of Z123212 is efficacious in reversing thermal hyperalgesia and tactile allodynia in the rat spinal nerve ligation model of neuropathic pain and also produces acute antinociception in the hot-plate test.

Liposomal encapsulation also significantly reduced mitoxantrone toxicity, allowing administration of higher, more efficacious drug doses.

Despite some clinical recommendations [ 327], no clinical studies have been performed to determine whether administration of PCC is efficacious and safe in managing bleeding in trauma patients who are not on vitamin K antagonists, although a swine model suggests that there may be some advantages [ 328].

Efficacious IFN inoculation was demonstrated only at the lower dose of 200mg total DNA, as previously described (5), while the dosage of 400mg total DNA suppressed the efficacy associated with individual administration of these IFN subtypes.