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Further, the utility of the instrument to detect change over time for determining treatment effects will need to be clarified.
Therefore, to increase the accuracy range of the numerical modelling approach, non-equilibrium effects will need to be incorporated in future models.
It is to mention that in our study, OC users had fewer chocolate servings per week than non-OC users, thus, the chocolate/cocoa effects will need further investigations.
Given the subtlety (most changes were < two-fold) and specificity (only ∼5% (294/5685) of expressed ORFs were significantly modified) of tif4631Δ on global translation (Fig. S6 and Discussion), the biological significance of these effects will need to be confirmed in downstream experiments.
For rare events like mortality, effects of zinc and iron can only be detected in large studies, so studies of interaction effects will need to be very large to detect real differences.
To be realistic components of a predictive algorithm for adverse reactions to radiotherapy, genetic effects will need to be robust in terms of replication and the central question will be their effect on an individual not a population, i.e., positive predictive value is more important than population attributable risk.
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Getting the balance right to maximise revenue and to have a deterrent effect will need careful consideration.
It is also worth noting that the sample size of regions primarily driving the latitudinal effect (e.g. the Orkney and Shetland Islands) and relatively small and so this effect will need to be confirmed in future work.
IPTc may allow greater exposure to malaria parasites than chemoprophylaxis thus facilitating the development of some naturally acquired immunity but if IPTc is widely deployed surveillance for a potential rebound effect will need to be maintained.
The distinct roles of beta-1 and beta-2 receptors in this effect will need to be determined in future studies.
In order to enhance the therapeutic window using cyclotherapy, specific and highly selective p53 activators that can induce a mild 'cytostatic' effect will need to be carefully selected.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com