Shortly, curcumin has received attention mostly due to its antioxidant, anti-inflammatory, antitumoral, apoptosis-inducing, and antiangiogenesis effects, which were reported in many investigations.
A potential confound that our design is not able to exclude is a possible influence of adverse drug side effects, which were reported by a majority of subjects in the DCS group (see Materials and Methods), on memory consolidation.
Interviewed patients and relatives were personally followed up by the primary physician shortly after the interview and checked for adverse effects (which were reported by only one patient participant who was strongly affected by childhood memories).
We therefore, also adjusted the random-effects models for the design effect (which was reported in relevant trials) from cluster-randomized trials.
Note that our results are conditional on whether the child is living with its biological mother, and on whether it is living with its biological father, the effects of which are reported in the appendix.
Most commonly seen treatment-related side effects are localized application-site reactions, which are reported as mild moderate by most patients who develop erythema or pruritus.
Only three rQTL overlap with main-effect loci, which were reported for this population in Norgard et al. (2011): r.4 for humerus/femur, r.23 for tibia/ulna, and r.28 for femur/humerus overlap with main-effect loci Lbn4.3 for femur and humerus, Lbn1.3 for tibia, and Lbn14.1 for femur and humerus.
The main adverse effect was neutropenia, which was reported in half of all treatment cycles, although grade IV neutropenia with complications was noted in only 15% of cycles.
Several studies evaluated the amino acid changes occurring in Arabidopsis leaf tissues infected with virulent Pst, virulent Pseudomonas syringae pv maculicola ES4326 (Psm) and other pathogens [ 37- 40], but none of them described the effects of Pst-AvrRpm1 which were reported in the current work.
We assumed an effect size of 4.87% which was reported in the combined sample of individuals with dyslexia (N = 699) and an effect size of 0.26% in a general population sample (N = 1080).
