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The QTL effects were validated in backcross populations.
The effects were validated in an embryonic kidney cell line (HEK293T) and in HLRCC-patient derived cells (UOK262) via both genetic and pharmacological inhibition.
Immune functions relevant to aging and inflammation, and to cancer and infections, and innate lymphoid cell effects were validated in vitro and in vivo.
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In addition, this effect was validated in the hip joint simulator FIME II.
Findings from in vitro and in vivo studies support this notion of proposed synergy, although this hypothesis can only be taken forward when the observed treatment effect is validated in various settings and in a larger number of patients.
Finally, the accuracy and reasonability of the two models of chloride diffusion coefficients for concrete and ITZ considering the effects of coarse aggregate were validated in terms of the meso-scopic finite element numerical simulation method for chloride diffusion into concrete.
The beneficial effects on survival rate were validated in the transgenic mouse line C57BL/6-TgN PDGFBEPO 321Zbz (tg6), which constitutively overexpresses human erythropoietin (Epo) cDNA, and in corresponding inbred wild type (wt) mice [ 12, 13].
We speculated that the joint effect of the genetic variations, which were validated in our study, provided a more strong association with risk of T2DM and IGR.
In this study, the effects of ellagic acid on inhibiting breast cancer angiogenesis were validated in vitro and in vivo.
In certain instances, these properties were validated in small animal studies (i.e. hypotensive effects).
90 SNPs with association P < 10-4 were validated in 9 additional sample collections and the results were combined using fixed-effects inverse-variance meta-analysis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com