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Success of these therapeutics and others is limited due to adverse side effects, tolerance and cost as evidenced by the increasing prevalence of disease1,4.
These results show that the same ethanol treatment can produce opposite effects (tolerance or sensitization) and demonstrate the involvement of Pavlovian conditioning in the development of tolerance.
Investigate the clinical and functional repercussion and evolution of the postmastectomy lymphedema as well as the existence of problems associated to the treatment (side effects, tolerance to treatment and patient collaboration) to establish an action guideline.
Benzodiazepine hypnotics, the mainstay of pharmacological treatment for insomnia, have been associated with altered sleep architecture, psychomotor and memory impairment, rebound insomnia, withdrawal effects, tolerance, dependence, abuse potential and respiratory depression.
A well-structured organization will help to improve the control on side effects, tolerance, and adherence.
In addition, without a structured organization, there will be no routine check on side effects, tolerance, and adherence [ 64, 69].
Similar(52)
Unfortunately, therapy-limiting maladaptations such as loss of treatment effect (tolerance), and paradoxical opioid-induced hyperalgesia (OIH) can occur.
This is why we might lose control over the use of the substance, may need more of it to have the desired effect (tolerance), or may experience withdrawal symptoms.
Maternal effect tolerance slope solutions for the dams of the offspring generation ranged from −18.9 to −10.8.
This variation in outbreeding effects on tolerance could reflect among-population variation in the underlying mechanisms of tolerance and/or in related allocation patterns (e.g., [21]).
It's very difficult though, alcohol effects and tolerance vary massively from person to person so determining your own thresholds subjectively is very difficult.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com