Sentence examples for effects the difficulty of from inspiring English sources

Major barriers to the clinical use of gene therapy, however, include transfection efficiency, the creation of long-term effects, the difficulty of controlling cell proliferation, ectopic transfection, disease transmission, patient-specific dose responses, immune reactions against viral proteins, possible side effects, and ethical issues [ 87, 88].

Flexibility in the mate search may help individuals to buffer the risk of not mating at very low densities, mitigate mate finding Allee effects (the difficulty of finding mates at low densities; [ 15, 23, 44]), and reduce the risk of population extinction when mates are limited or costly to find [ 45, 46].

The analysis of PCB effects illustrates the difficulty of separating the effects of two correlated exposures both measured with error and where error adjustment is conducted by different approaches.

Six items were manipulated to have linear position effects and the difficulty of the remaining items were not influenced by position changes.

5 Historically, initial treatment of hypertension with combination therapy has been discouraged because of concern about excessive reduction in BP, increased side effects and the difficulty of attributing adverse events to one drug.

Schopenhauer finds tragedy to be the summit of poetical art, because of the greatness of its effect and the difficulty of its achievement.

This is probably an effect of the difficulty of maintaining a fixed speed in driving simulators [33].

Another side effect is the difficulty of achieving efficiency within the whole life cycle of the converted resources.

We attribute this main effect to the difficulty of perceiving and localising several simultaneous touches.

Such "off-target" effects greatly increase the difficulty of identifying the genes actually responsible for the selected phenotype.

These interaction effects further aggravate the difficulty of determining hazard.