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Effects resultant from altered protein function in addition to those resulting from global hyperacetylation and derepression of gene expression, adds a new level of complexity to the mechanism(s) of action of HDACIs and explains several answered questions that the simpler histone-only model could not easily explain.
Through encapsulation of the cytotoxic agent, they reduce the potential for side effects resultant from free circulating drug (Ranson et al, 1997).
Another more biologically oriented definition of Pharmacometrics is " the branch of science concerned with mathematical models of biology, pharmacology, disease, and physiology used to describe and quantify interactions between xenobiotics and patients, including beneficial effects and side effects resultant from such interfaces".
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The simulations show how matrix cracking is affected by discontinuities in the fiber angle between adjacent courses and fiber-free areas resultant from manufacturing effects; whereas fiber tensile failure is directly influenced by the orientation angles of the fiber, whose distribution depends on the chosen course cutting method: on one side, or on both sides.
Purified laminin significantly increased the growth of sc tumours resultant from co-injection with either WiDr or A549 cells, whereas collagen IV or laminin with entactin showed no such effect.
An identification task was selected in this study because we hypothesized that effects of categorization training on discrimination would be secondary to (resultant from) the effects of categorization training on identification and may not be observable within 4 training sessions.
MEG measures the magnetic field outside the head: in effect, the resultant field from the flow of current inside the brain.
The effect of PICP in promoting rapid vessels formation and organization might be resultant from its chemoattractant effect on endothelial cells, shown in vitro studies [ 37].
Moreover, we excluded the hypothesis that the restoration of ACE2-Angiotensin(1 7)- Mas axis functionality in carotid arteries from angiotensin-(1 7 -treated diabetic rats could be resultant from a translational effect of enhancing ACE2 or Mas receptors expression, since they remained unaltered after the treatment.
It is thought that cardiac effects of glucagon are considered to be resultant from stimulation of glucagon receptors associated with Gs protein [ 31].
Cardiac effects of glucagon are considered to be resultant from stimulation of glucagon receptors associated with Gs protein, which cause adenylyl cyclase (AC) activation and the consequent increase of 3′,5′,-cyclic adenosine monophosphate (cAMP) production [ 31].
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