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Alternatively activated T-cells could be eliminated by pretreatment with cyclophosphamide and anti-tumour effects restored.
Thus, it is assumed that the enhanced anti-tumor or anti-viral effects restored by the anti-Tim-3 and PD-1 antibodies were due to the removal of negative regulation from CD8+ T cells.
These projections yielded average ratios of 'life-years gained per patient-year of and'lives 'livesaveded per patient on ARV', which varied among countries and over calendar years according to varying stages of disease that patients initiated ARV, indirect demographic effects (restored fertility etc)., and dynamic effects of ARV, through reduced viral load, on reducing HIV transmission.
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In combination with the effects of solution transfer within SISZ, silicification arising from serpentinization has multiple effects—restoring cohesive strength to existing fractures, reducing porosity, precipitating low-permeability seals, and promoting overpressuring in areas of fluid release.
On the contrary, some recent animal data suggest that DPP-IV inhibitors might have cardioprotective effects, restore tissue perfusion and promote homing of stem cells to injured areas [ 13, 14].
It has, in effect, restored their rights to education and expression.
(The Trade Reform Bill of 1974, however, in effect restored to the U.S. president the authority to designate preferential tariff treatment, subject to approval by Congress).
The afternoon of his victory he fires Sears, political director Charles Black and press secretary Jim Lake in a shakeup that in effect restored Reagan as head of his own campaign.
Under Kerrys proposal, the government would, in effect, restore community rating for catastrophic medical care.
A Tory government would instead focus on repatriating social and employment laws, in effect restoring the British opt-out from the social chapter.
In a speech last week, Mr. King said policy makers should consider breaking up the largest banks and, in effect, restore the Depression-era barriers between investment and commercial banks.
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