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On the basis of their mechanism of action (cell killing during DNA replication) and the potential reversibility of the drug effects, protracted therapy with camptothecins is reported to provide optimal antitumour effects.
As neoadjuvant and adjuvant chemotherapy schedules often consist of multiple treatment cycles over relatively long periods of time, it is important to know what effects protracted drug administration can have on the immune system.
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Act I introduces teenage love and time travel; Act II explores adult heartbreak and machines with feelings; Act III combines all of these with the physical, psychical and emotional effects of protracted longevity.
This finding adds to the limited data on the carcinogenic effects from protracted environmental ionising radiation in the low-to-medium dose range.
The remaining Offices continue to deal with the effects of protracted civil wars or ongoing HIV/AIDS emergencies (Botswana, Eritrea, Lesotho, Swaziland, Uganda and United Republic of Tanzania).
For experiment 3 examining specificity of CP 94,253 effects during protracted abstinence, a one-way ANOVA was used with 5-HT1B receptor ligand type (i.e., vehicle, SB 224289, CP 94,253, or SB 224289 + CP 94,253) as the between-subjects factor.
Further, it is notable that postnatal CAPS was associated with behavioral toxicity that was present several months following the end of exposures, suggesting that developmental CAPS exposures can have protracted effects, thereby underscoring the need for further evaluation of air pollution effects on the CNS and how such exposures may contribute to CNS diseases and disorders.
CITY HALL — The historic Alex Theatre continued to struggle with the effects of a protracted recession last year, selling fewer tickets and bringing in less revenue compared with the year before, according to the organization's year-end report.
At the end of the study, changes in tumor size were not significantly appreciable, suggesting that the anti-tumor effects can be protracted after discontinuation of therapy.
It is known that various stress conditions may produce protracted effects on genome stability, leading to transgenerational changes in genome structure, which are proposed to have been initiated by epigenetic mechanisms [ 31- 37].
The effects may be protracted: one study reports ongoing verbal memory decline up to 9 years after left temporal surgery (Rausch et al., 2003), and two others report short-term decline followed by stabilization or recovery after 6 10 years (Alpherts et al., 2006; Andersson-Roswall et al., 2010, 2012).
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