Chem2Bio2RDF is a single RDF repository covering over twenty public data resources pertaining to drugs, chemical compounds, carcinogens, protein targets, genes, diseases, side effects, pathways and their relations [7].
Interestingly, although both receptors display convergent effects, pathways underlying CB1 effects are markedly different from those affected by CB2.
The major effect pathway by which they operate is the endogenous apoptotic pathway.
The relational database schema used in our system is designed based on the category of bio-terms (compound, drug, gene, disease, side-effect, pathway) and DTD (Document Type Definition) provided by National Library of Medicine (NLM).
Figure 2 demonstrates the metformin effect pathway on T2D model.
According to the metformin effect pathway, metformin targeted PRKAB1 enzyme in hepatocyte.
It shows integrated drug effect pathway of metformin in the rules [ 20].We simulated effect of single drug at each simulation step among twenty-two drugs.
34 37 The DAG clarified how a number of the potential confounding variables were intermediate variables in the theoretical effect pathway and therefore, not true confounders.
To unravel the biological relevance of these effect pathways, we applied a 2 × 2-factorial test design.
