Perhaps most importantly, we analyzed the effects of tolerability on the number of measurements one can expect to obtain from studies of participants in which ambulatory BP monitoring is used.
We have explored in detail the relationship between Ab evolution and the pharmacokinetics and pharmacodynamics associated with pegloticase therapy, as well as the effect on tolerability.
Furthermore, increasing the dose of epirubicin from 50 to 75 mg m−2 appears to improve the response rates in patients with advanced breast cancer who are treated with the FEC regimen, with no significant effect on tolerability (French Epirubicin Study Group, 1991; Ormrod et al, 1999).
It should be noted, however, that medications used in the older patient group and the younger patient group were not significantly different with respect to the effect on antiretroviral tolerability and response.
The combination regimen was well tolerated with no adverse effects on the safety, tolerability and pharmacokinetics of either agent.
The combination of Cilengitide and gemcitabine was well tolerated with no observed differences in the treatment groups on either adverse effects on the safety, tolerability and pharmacokinetics.
The present study was undertaken to assess this potential pharmacokinetic interaction by evaluation of the simvastatin plasma concentration vs time profiles after coadministration with imatinib (US Department of Health and Human Services, 1999) and its effects on safety and tolerability in patients with chronic myeloid leukaemia (CML).
We believe this missing information was crucial, as side effects had a bearing on tolerability of the interventions.
In the development of the TSQM, an initial set of 55 items were drafted to represent the conceptual framework of TS-M identified based on qualitative research which included the concepts of effectiveness, symptom relief, side effects, convenience, tolerability, impact on daily life and functioning and global satisfaction [ 19].
Combination treatment had additive effects on BP reduction, and tolerability was similar to valsartan [ 103].
