A polymorphism leading to an amino acid substitution in one allele could have strong effects on the function of a di- or multimeric protein and polymorphisms in noncoding regulatory regions could result in skewed transcription and altered protein levels.
Although it is difficult to directly extrapolate clinically effective dose ranges from in vitro studies, these findings of direct Acthar effects on the function of activated human B lymphocytes have implications for the treatment of autoimmune diseases characterized by B-cell activation and humoral autoimmunity.
Gene-regulatory networks are coupled in turn to other networks that have profound effects on the function of systems and thereby determine evolutionary possibilities.
Its effects on the function of the ischemic bladder are not known.
Their effects on the function and expression of P-glycoprotein were detected using Western Blot and RT-PCR.
Spinal cord injury (SCI) leads to an inflammatory response and generates oxidative stress, which has deleterious effects on the function of several organ systems, including the urinary bladder.
This study was designed to understand the transport profiles of astilbin and taxifolin in Caco-2 cell model and their effects on the function and expression of P-glycoprotein.
To determine whether thyroid hormones play a role in β-cell proliferation, Ximenes et al. (2007) reported that high concentration of T3 (>250 µmol/L) attenuated β-cell proliferation, increased apoptosis and decreased the secretion of insulin, while physiological concentrations of T3 have no negative effects on the function and survival of β-cells.
Our data suggests that the tissue origin of the cellular microenvironment has effects on the function of EndoC-βH1 cells in vitro, and the use of a more human-like culture microenvironment may bring benefits in terms of increased physiological relevance.
