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These results demonstrate a clear positive association between effects on progression and survival in MBC patients, which is statistically significant.
Thereby, interventions that may positively affect bone turnover, may in theory have secondary positive effects on progression of OA.
These diluting factors make it hard to confirm the link between effects on progression and effects on survival.
However, use of GM-CSF and G-CSF treatment in MDS has been limited due to concerns about effects on progression, safety, and side effects [ 16].
The plot of effects on progression and survival illustrates the wide heterogeneity of results across studies conducted in metastatic breast cancer patients.
No significant CFH genotype treatment interaction effects on progression were observed when the analysis additionally included patients with an earlier disease stage (AREDS category 2) [ 87].
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The effects on progression-free survival (PFS) and overall survival (OS) were also analyzed.
In the case of the anti-EGFR monoclonal antibodies, panitumumab and cetuximab, treating patients with activating KRAS mutations may result in detrimental effects on progression-free survival (Bokemeyer et al, 2009; Douillard et al, 2010), further emphasising the need to maximise the detection of KRAS activating mutations.
The relative survival effect is expected to be about one-third of the relative effect on progression.
In contrast, HSV-1 and HHV-8 showed a strongly protective effect on progression from fibroadenoma to breast cancer.
It is noteworthy that none of the respondents had gone through a MD-PhD intercalated degree at medical school, but such programmes have been shown to have a positive effect on progression to a clinical academic career [10].
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