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In infants born with the disease, abnormally low activity of the enzyme hexosaminidase A allows an unusual sphingolipid, ganglioside GM2, to accumulate in the brain, where it soon exerts devastating effects on neurological function.
We speculate that the rapid decline of the TP-10 treated mice at week 14 of age may have been due to this feature of the phenotype that overwhelmed the beneficial effects on neurological function.
While there was no functional improvement following MSC transplantation, no serious adverse effects and no detrimental effects on neurological function were reported [ 51].
Disruption of neuronal morphogenesis in the developing nervous system by pyrethroids could result in detrimental effects on neurological function later in life.
Fish are also a good source of poly-unsaturated fatty acids, selenium and Vitamin D, all of which have beneficial effects on neurological function that may help counter the harmful effects of mercury [ 74, 75].
This hypothesis suggests that estrogen has beneficial effects on neurological function if neurons are intact; however, oppositely, if neurological health has already been compromised, estrogen may exacerbate neurological impairment.
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The neuroprotective effect of sevoflurane preconditioning was partially reversed by down-regulation of TREK-1 with siRNA, as supported by the deleterious effect on neurological function and increases in infarct volume after MCAO.
We detected no evidence of a publication bias after a funnel plot analysis, but there was significant heterogeneity (p = 0.005) and substantial heterogeneity (I = 81%%) among the trials in the effect on neurological function (Additional file 7: Figure S6a and b).
This also suggests that strategies which increase Akt or decrease PTEN expression or function, such as growth factors to prevent neuronal death, may have a paradoxical effect on neurological functioning by inhibiting striatal responses to dopamine.
The overall effect of MIH on neurological function at 6 months or 180 days was estimated from only three trials of 1348 patients.
The overall effect of MIH on neurological function at hospital discharge was estimated from five trials, which included a total of 1372 patients.
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