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A recent meta-analysis evaluated 5 randomized, double blind and controlled studies in all of which no adverse effects on liver function were reported [66].
In this work we evaluated the effects on liver function of a C. majus extract, obtained from the herbal material responsible for one case of hepatotoxicity.
PB accomplishes its diverse effects on liver function in part by promoting a nuclear translocation of the constitutive androstane receptor (CAR) [30].
But at sustained high doses, ethanol has health risks associated with its effects on liver function, lipids, coronary heart disease, hypertension, stroke, diabetes, dementia, and cancer progression [4], [5], [6].
In future studies when evaluating the efficacy of tumor antigen specific vault nanocaspsules vaccination routes in the protective and therapeutic settings that include i.v or i.p. delivery routes, changes in plasma/serum transaminase level will be quantified for vault effects on liver function.
Despite the observed changes at the molecular level, there were no evident systemic long-term negative effects on liver function.
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Generally, hepatic steatosis, the accumulation of lipid in the hepatocytes, has negative effects on liver functions, which may be resulted or caused by inflammation.
Ursolic acid alone (10 or 20 mg/kg) had no effect on liver function.
In a report of 35 patients <1 year of age who received oseltamivir, no AE occurred and no effect on liver function was detected [31].
It is currently unclear whether endogenous Smad7 has an effect on liver function and alcoholic liver damage.
CQ or rapamycin alone showed a slight shrinkage, suggesting that they had no significant effect on liver function.
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