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Moderate level over-expression of MnSOD has beneficial effects on life span.
Recently, Simons et al. have shown that mice with heterozygous deficiency of PI4KIIα do not display effects on life span (Simons et al., 2009).
By manipulating individual genes and measuring effects on life span, researchers could test the role of specific molecular pathways in aging.
Sexual differentiation often has significant effects on life span and aging phenotypes.
When dSir2 and DN-Dmp53 are expressed together, no additive effects on life span are observed.
The I4 lethal effect was discovered during a study of temperature effects on life span.
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It has only a modest effect on life span, but it causes costly chronic illnesses, like diabetes.
Now, with the new study, researchers are asking why the University of Wisconsin study found an effect on life span and the National Institute on Aging study did not.
But there is no proof that calorie restriction works in people, largely because it is difficult and expensive to study; it can also take decades to measure an effect on life span.
It looked at various markers of disease but did not try to assess resveratrol's effect on longevity, given that rhesus monkeys live 40 years and it takes a long time assess any effect on life span.
When the receptor gene's function was restored in other tissues, like nerve or muscle, the cells' metabolic response to insulin was restored but there was no change in their life spans, confirming that the gene's effect on life span is mediated via the brain cells.
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