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However, our data cannot exclude minor effects on interaction or TSC2 stability.
Model systems offer particular advantages for establishing general principles because specific changes in peptide sequence and structure can be made, and the direct effects on interaction with a surrounding lipid membrane can be analyzed.
The different rates of uptake of CRLPs oxCRLPs and pCRLPs by macrophages demonstrated here, therefore, could be explained by effects on interaction with the LDLr and the LRP caused by differences both in the conformation of apoE and in the number of apoE molecules able to bind to the receptors, even though the total amount of apoE associated with the particles is not changed.
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We found strong canopy and climate conditions effects on interactions between understory shrubs and oak transplants.
To better understand the light effects on interactions overstory-understory, we consider that a month-by-month analysis is necessary in a next research phase.
However, the modulating role of nutrients in C and N cycles, and their resulting effects on interactions between methanogenesis and denitrification are poorly understood.
By augmenting lobster populations, which are primarily fished within 5 10 km of the coast, herring subsidies are likely having additional indirect effects on interactions between lobsters and their natural prey.
Whether the role for TLR is confined to autoantibody production remains unclear; TLR may exert key effects on interactions between B cells and T cells, as well as on T-cell regulation mechanisms.
Given its reportedly critical role in embryonic mammary gland development, loss or alteration of stromal Msx-2 function in the adult mammary gland might be expected to have profound effects on interactions between the neoplastic epithelium and its associated stroma.
Therefore in addition to stabilisation of the kinase domain by linking the C-terminal lobe to the N-terminal lobe via MO25, there may also be direct effects on interactions at the active site.
Importantly, the analysis was able to identify mutations falling in the interfaces and to predict their effects on interactions such as of IL-10 with its receptors, IL-10 with A2M, and A2M with APP and KLK13.
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