These results suggest that loss of functional UBE3A expression, in addition to perturbing the turnover of its known cellular substrates, can also have more far reaching effects on general proteasome function and hence on the normal cellular homeostasis.
Mutations or interventions that extend lifespan and stress resistance may have either positive or negative effects on general vigor or function of major organ systems.
Obesity has detrimental effects on general health and respiratory function.
The aim of this review was to discuss the results of previously published studies on the possible effects of NE on general cognitive functioning, educational achievement, neuropsychological functioning and behavior from infancy through adolescence.
In general, migraine has a profound effect on wellbeing and general functioning, not only during attacks but also in terms of work performance, family and social relationships, and school achievement [2].The WHO rates it among the most disabling, and costly, chronic disorders [7].
Migraine has a profound effect on wellbeing and general functioning, not only during attacks, but also in terms of work performance, family and social relationships, and, mainly in children, school achievement, thus explaining why the WHO expert panel rates migraine among the most disabling and costly chronic disorders.
Previous analytical reviews identified several potential mechanisms of how whole body vibration may exert its beneficial effects on neuromuscular function in general and on athletic performance in particular (Nordlund and Thorstensson 2007; Rittweger 2010).
Harmful effects of electromagnetic fields (EMF) on cognitive and behavioural features of humans and rodents have been controversially discussed and raised persistent concern about adverse effects of EMF on general brain functions.
Instead, Table 4 provides the next step in a rational approach towards the design and interpretation of studies that aim to establish effects on immune function in the general population.
Genetic ablation of specific PcG genes in mice has confirmed their role in embryonic patterning and Hox gene regulation but also pointed to more general effects on stem cell function.
