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However, direct effects on eosinophil function remain to be definitively demonstrated.
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Leptin exerts both direct and indirect effects on eosinophil chemotaxis and intracellular signalling.
PGD2 has been shown to have chemokinetic effects on eosinophils and T helper type 2 (Th2) cells in vitro.
The inhibitory effect on eosinophil peroxidase could provide at least in part an explanation of the therapeutic efficacy of dapsone in eosinophil-mediated diseases (e.g. eosinophilic fasciitis).
Administration of anti-CD8 antibody had no effect on eosinophil numbers (Figure 5D).
The effect on eosinophil influx was also synergistic in the maxilloturbinates but less than additive in the septum.
However, some of our observations are inconsistent; for example, the gap junction inhibitor 18-a-glycyrrhetinic acid had a pronounced effect on eosinophil transendothelial migration but did not affect dye transfer between eosinophils and endothelial cells.
There was also a significant increase of eosinophils at this time point after OVA challenge, while CTCM treatment, either before or after OVA challenge, had an inhibitive effect on eosinophil infiltration in BALF, as shown in Figure 5.
Our results show that SSTW had a suppressive effect on eosinophil influx into BALF and decreased the levels of Th2-type cytokines.
However, their effects on myocardial function diverged.
They exhibit beneficial effects on sperm function.
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