Additionally, analysis of deletion mutants in which paralogs that encode a single glycolytic enzyme are inactivated cannot reveal synergistic effects of the minor paralogs of different glycolytic enzymes.
Despite the previous findings of an association of the rs10744676 KCNA5 genetic variant with PAH+ SSc patients, our data do not corroborate the reported protective effect of the minor allele of this polymorphism on SSc-related PAH.
Because of the limitation that sample size exerts on association studies, we attempted to extract extra information from our data to elucidate the susceptibility effect of the minor allele of this polymorphism.
Using the polygenic and mmscore functions available in GenABEL we tested the additive effect of the minor allele (T) for this SNP on the transformed plasma Aß phenotypes including covariates for age and sex in the model.
We adjusted both SAR and HSMR for deprivation but found that the effect of this was minor and did not change our conclusions.
This further underlines the remarkable effect of the minor differences in the amino acid sequences of the Fab fragments to their binding characteristics.
The effect of the minor change is verified through noise dynamometer tests.
So that the effect of the minor variables can be minimized.
However, the effect of the minor head loss on the flow rate is negligible.
The effect of the minor cracks, voids and inclusions on the fatigue life of the material is discussed in detail.
