Sentence examples for effects of these variants from inspiring English sources

This review will focus on the most common and widely studied SNPs of oxidative DNA damage repair proteins trying to bridge the information available on biochemical and structural features of the repair proteins with the functional effects of these variants and their potential impact on the pathogenesis of disease.

"The effects of these variants didn't just add together in a simple way," says Burn. "There were some situations where a variant was a disadvantage unless it was in the presence of another variant when it became an advantage.

We aimed to replicate this finding in an independent cohort from the Study of Viral Resistance to Antiviral Therapy of Chronic Hepatitis C and to investigate the effects of these variants beyond week 4. METHODS:Genetic material was available from 318 patients.

These consistent findings from three independent cohorts strongly support the risk effects of these variants on GSIS to predispose hyperglycemia in Chinese.

Thus the effects of these variants on clinical characteristics in the Chinese still need to be investigated in cohorts with more samples.

However, Heni et al showed the impact of genetic variation on insulin secretion depends on glycaemia [25], [26], what are the effects of these variants in the diabetic patients and prediabetes subjects remained unknown and to be investigated.

Table 1 shows that the effects of these variant RNA sequences (shown in Figure S2) are negligible: all of the hairpin RNAs have affinities for JAZ ZF34 similar to that of T57A RNA (C50 ≈ 60 80 nM).

Given the availability of smoking measures in our sample, we also tested if an effect of these variants on smoking quantity (CPD) or nicotine dependence (FTND) was detectable in our sample.

Subsequent studies of the effect of these variants on estimates of the beta-cell function and insulin sensitivity have been inconclusive.

Hence, investigating the effect of these variants in combination with other genetic variants or environmental factors would help elucidating their potential role in NAFLD.

In addition, because esophagitis typically presents 4 6 weeks following initiation of radiation therapy, we also analyzed the effect of these variants using logistic regression.