Exact(2)
In plant genomes, heterochromatin is marked by methylation of cytosine and methylation of histone H3 at lysine 9. Heterochromatin formation is targeted to transposons as a means of defending the host genome against the deleterious effects of these sequences.
To determine the in vivo effects of these sequences, we replaced the upstream regulatory sequences of the HIS4 gene of Saccharomyces cerevisiae with either 12 or 48 tandem copies of CCGNN.
Similar(58)
We did identify base changes in several candidate genes, indicating a low rate of EMS effects on these sequences.
To determine whether the effects of these sequence determinants are additive, we assayed peptides that had various combinations of local and distal sequence.
We evaluated the missense variants using various predictive tools (SIFT, polyphen, Align GVGD, pMUT and PANTHER) and combined these with data available from previous studies on functional effects of these sequence variants.
The effects of these sequence variations in the κB sites have been studied in depth and their affinity appears to be dependent on the nature of the co-activators engaged in the stabilization and activity of the NF-κB complexes [ 2].
One recurring motif involves juxtaposing quotations from Mr. Kim's film writings with scenes from North Korean movies that appear to illustrate them; the primary effect of these sequences is to make you wish you could see more of the North Korean films.
We are presently investigating the protective effect of these sequences against live influenza challenge.
The current names of pasteurellacean uptake signal sequences (USS) and neisseriacean DNA uptake sequences (DUS) could be misleading, as they do not accurately describe the effect of these sequences on DNA uptake and imply that they represent different genetic elements.
Manual evaluation of positively selected genes involved examination of the alignments, where in families with branches with Ka/Ks>1 and alignments where some sequences had a high percentage of gaps, the effect of these sequences on the alignment and subsequent calculation of Ka/Ks ratios was evaluated.
We will investigate the functional effect of these sequence changes in future work.
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