Sentence examples for effects of these mutant from inspiring English sources
Although we cannot confirm that the Fbn2tm1Rmz, Fbn2fp-2J and Fbn2fp-3J alsoles also result in a homozygous phenotype of reduced strength, we feel it is highly likely given the likely effects of these mutant alleles on the Fbn2 protein and the similar digit fusion phenotype.
Whilst the cellular response to mutant matrilin-3 and COMP expression has been documented in detail (Bell et al., 2012; Leighton et al., 2007; Piróg-Garcia et al., 2007; Suleman et al., 2012), the effects of these mutant proteins on the organisation and composition of the cartilage ECM are not clearly defined.
To further analyze the effects of these mutants overexpression in cell cycle, and being p27 mainly involved in G1/S transition, we studied more in details how T198 substitution affects this event.
Effects of these mutants on complex maturation were analyzed by Western blot of cell lysates and densitometry.
As can be seen, this reversed the inhibiting effects of the AS-mutants, suggesting that the effects of these mutants on proteasomal activity is via inhibition of S5a.
Examination of the effects of these mutants in the context of tandem K2P2.1 (TREK-1) channels further demonstrates that the effects of Ct activation are transmitted through M4 by a cis-type mechanism.
At this point, further studies are necessary to demonstrate a possible potentiation of the positive effects of these mutants from E. coli with the seemingly protective function of carbohydrate structures from a glycosylating production host.
There was also a small but significant increase in the number of Ptbx-2:: gfp expressing neurons in the head and tail expression that might result from additive effects of these mutants.
The phenotypic effects of these mutants appear to result from functional changes in the Sse1 protein and are not due to changes in expression levels of other chaperones known to influence prion propagation.
Genome-wide expression profiling revealed that the effects of these mutants on mitotic functions are congruently reflected in G2/M gene expression networks in a manner that mimics the on and off states for P-Ser-HP1γ.
