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Exact(31)
Thereafter, doxycycline was omitted for varying periods to assess experimental effects of the mutant HIF-1α transgene.
Alternatively, they may occur early on, in relation to the disease process, i.e., to proximal effects of the mutant huntingtin protein.
A consistent finding from the analyses indicates that the R403Q cardiac phenotype is due to the dominant effects of the mutant on sarcomere function.
The aforementioned deviations from Mendelian expectations (Table 1) may be the result of viability effects of the mutant chromosomes or the wild-type chromosomes.
Conversely neural inertia can be narrowed by genetic manipulation as demonstrated by the effects of the mutant allele Shmns in Drosophila.
The different effects of the mutant alleles in these assays is unlikely to be due to differences in the ability to survive DSBs as plating efficiencies are substantially similar (Table 1).
Similar(29)
The most dramatic effects of the mutants were observed in their abilities to recognize termination codons.
The growth inhibitory effects of the mutants correlated with their effects on AR transcriptional activity in LNCaP cells.
This is evident based on the effects of the mutants of a nuclear A. thaliana E3 sumo ligase Siz1.
In contrast, the mutant BAP1 constructs showed reduced or no inhibitory effects according to the possible deterioration effects of the mutants (Fig. 3a).
Despite the relatively subtle effects of the mutants on the measured rate constants, the high correlation coefficient (r = 0.993) is unlikely to be coincidental (p=0.0045; 'Materials and methods').
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